2026 NFL Odds Week 2: Lines, Spreads, Results For All 16 Games

Week 2 is in our sights, headlined by a Thursday night clash between the Lions and the Bills in Buffalo. Here are the lines for every Week 2 matchup at bet365 Sportsbook as of Sept. 18. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. Lions 31, Bills 41 Spread: Bills -4.5 (BUF covers)O/U: 54.5 (Over hits) Panthers @ Falcons Spread: Panthers -2.5Moneyline: Falcons +125, Panthers -150O/U: 43.5 Bengals @ Texans Spread: Texans -2.5Moneyline: Texans -150, Bengals +125O/U: 46.5 Browns @ Buccaneers Spread: Bucs -8.5Moneyline: Bucs -425, Browns +325O/U: 41.5 Packers @ Jets Spread: Packers -3.5Moneyline: Packers -190, Jets +160O/U: 44.5 Vikings @ Bears Spread: Bears -4.5Moneyline: Bears -225, Vikings +185O/U: 48.5 Saints @ Ravens Spread: Ravens -8.5Moneyline: Ravens -425, Saints +325O/U: 46.5 Eagles @ Titans Spread: Eagles -7Moneyline: Eagles -340, Titans +270O/U: 39.5 Steelers @ Patriots Spread: Patriots -5.5Moneyline: Patriots -245, Steelers +200O/U: 41.5 Jaguars @ Broncos Spread: Broncos -2.5Moneyline: Broncos -150, Jaguars +125O/U: 45.5 Raiders @ Chargers Spread: Chargers -6.5Moneyline: Chargers -300, Raiders +240O/U: 43.5 Dolphins @ 49ers Spread: 49ers -13.5Moneyline: 49ers -1000, Dolphins +650O/U: 45.5 Seahawks @ Cardinals Spread: Seahawks -3.5Moneyline: Seahawks -205, Cardinals +170O/U: 41.5 Commanders @ Cowboys Spread: Cowboys -4.5Moneyline: Cowboys -210, Commanders +175O/U: 50.5 Colts @ Chiefs Spread: Chiefs -6.5Moneyline: Chiefs -300, Colts +240O/U: 46.5 Giants @ Rams Spread: Rams -7.5Moneyline: Rams -350, Giants +275O/U: 48.5